Odion Ighalo scored his first brace for Manchester United to guide them into the FA Cup quarter-final with a comprehensive 3-0 win at Derby County.
Manchester City produced a scintillating comeback to defeat 13-time champions Real Madrid 2-1 at the Santiago Bernabeu.
Serge Gnabry stunned Chelsea with two goals in quick succession to inspire Bayern Munich to a 3-0 win at Stamford Bridge.
Bayern Munich move four points clear at the top of the Bundesliga with a cagey 3-2 win over bottom-place Paderborn at the Allianz Arena.
Liverpool have progressed into the quarter-final of the Premier League International Cup after coming from two goals behind to draw 2-2 against Wolverhampton Wanderers at Molineux.